Description: Halcinonide is designated chemically as 21-Chloro-9-fluoro-11β,16α, 17-trihydroxypregn-4-ene-3,20-dione cyclic 16,17-acetal.

Pharmacological effects: This product is topical corticosteroids efficient fluorine and chlorine, with anti-inflammatory, anti- itching and vasoconstriction. This product is in the skeleton of triamcinolone, the chlorine atom instead of 21 hydroxy, the vasoconstriction test determination of anti-inflammatory potency multiples of 360, there is evidence that the intensity and efficacy of vasoconstriction test is consistent. Antipruritic mechanism of anti-inflammatory β receptor protocatechuic acid-amine reaction, through the activation of adenylate cyclase CAMP generate increased phosphoric acid ethyl ester and inhibit the enzyme CAMP destruction reduce the results of cAMP in the cells concentration increased, while inhibition of the release of histamine. This product inhibition granulomatous hyperplasia in rats and mice the role of dexamethasone similar. Swelling was observed, caused by formaldehyde in mice and rats after the heel of the goods and dexamethasone significantly inhibited, with five times the amount of hydrocortisone had no inhibitory effect. The product of the thymus and spleen have a significant role in weight loss.
reduce T lymphocytes, monocytes, the number of eosinophils, inhibition of lymphocyte proliferation and cytokine production, inhibition of macrophage differentiation and phagocytic activity , inhibition of neutrophil adhesion, reducing the permeability of endothelial cells, inhibition of fibroblast proliferation and collagen synthesis, inhibiting the activity of sebaceous gland cells.This product has anti-mitotic effect, which reduces the transcription of DNA, thereby reducing the synthesis of DNA, but also affect the dna repair, resulting in epidermal thinning, especially for the synthesis of collagen the greatest impact .The product of the corticosteroid receptor through the cytoplasm combined with a series of reactions occurs, activate the expression of cell lysis gene "; it induced nuclear lymphocytes dna cleavage direct cytotoxic lymphocyte death.

Pharmacokinetics: Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Indications: Relieving itching, irritation, redness, and swelling associated with many skin conditions.

Precautions:  Halcinonide cream in for topical use only.Apply a small amount of medicine to the affected area. Gently rub the medicine in until it is evenly distributed.Wash your hands immediately after using halcinonide cream unless your hands are part of the treated area.If you miss a dose of halcinonide cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not apply 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist.Halcinonide cream is for external use only. Do not get halcinonide cream in your eyes. If contact is made with the eyes, flush them immediately with tap water.If halcinonide cream was prescribed to treat the diaper area of a child, avoid using tight-fitting diapers or plastic pants.Halcinonide cream contains a corticosteroid. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains hydrocortisone or any other corticosteroid. Do not use halcinonide cream for any other skin condition.Halcinonide cream may be more likely to be absorbed into your body with high doses or prolonged use. Do NOT exceed the recommended dose .

Adverse reaction: Dry skin; mild, temporary burning, itching, or stinging.Seek medical attention right away if any of these SEVERE side effects occur:Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; excessive hair growth; inflammation of hair follicles; persistent or severe burning, itching, redness, or swelling of the skin not present before using the medicine; skin discoloration, irritation, or thinning; stretch marks.