Description: This product is colorless to light yellow clarity liquid, its chemical name is diclofenac Sodium: 2-[(2,6-dichloro-phenyl)amino] phenylacetic acid sodium. lidocaine Hydrochloride: N-(2,6-dimethyl-phenyl)-2-diethylamino-acetamide hydrochloride.

Pharmacological effects: diclofenac sodium is a derivative of phenylacetic acid class of non-steroidal anti-inflammatory analgesic, its mechanism of inhibition of epoxidation activity, thereby blocking the conversion of arachidonic acid to the prostate gonadotropin. The same time, it can also promote arachidonic acid and triglyceride combination to reduce the concentration of intracellular free arachidonic acid, while the indirect inhibition of leukotriene synthesis. Strong a role in the diclofenac non-steroidal anti-inflammatory drugs, its prostate prostaglandin synthesis inhibition is stronger than aspirin and indole indomethacin, etc. diclofenac sodium also has to prevent platelet aggregation. For the absorption of the amide local anesthetic, blood or intravenous lidocaine, significant excitatory and inhibitory biphasic effect and no pioneer in the excitement of the central nervous system, the plasma concentration is low, analgesic and somnolence, pain threshold to improve. The compatibility between the two, since analgesic synergy.

Pharmacokinetics: diclofenac sodium after intramuscular injection, plasma protein binding rate was 99.5%, about 50% metabolized in the liver, 40% - 65% is excreted from the kidney, 35 % from the bile, feces.after the lidocaine injection, tissue distribution of fast and wide, through the blood - brain barrier and the placenta. anesthesia strength of this product, rapid onset, diffuse and strong to eliminate drugs from the local take about two hours. Most of the first reduced by hepatic microsomal enzymes are still local anesthesia the middle of the de-ethyl metabolite monoethyl GLYCINAMIDE xylene, toxicity increased by amidase hydrolysis, excreted in the urine, about 10% of the amount of the prototype discharged a small amount in the bile.

Indications: This product is analgesic drugs. Mainly used for pain caused by the following diseases:muscle, joint, joint capsule, synovial capsule, tendon, tendon sheath, and the lumbar spine inflammation, pain caused by joint degeneration and extra-articular rheumatism. Such as chronic rheumatoid arthritis, ankylosing spondylitis, vertebral dislocation of the joint disease, arthritis, spine and joint disease, the painful vertebral syndrome, ankylosis Lian Xing spondylitis soft tissue rheumatism, bursitis, tendonitis, back pain and sciatica , cervical syndrome and some cases of neuritis, neuralgia. cute gout attack. non-rheumatoid inflammatory pain.kidney twist pass and biliary twist through. Injury or postoperative pain, inflammation and swelling.

Precautions: The gastrointestinal tract disease, peptic ulcer, ulcerative colitis, enteritis, or liver dysfunction, cardiac function or renal function, patients taking diuretics, elderly patients, as well as any cause extracellular fluid less than patients in the using this product should be used with caution, and strictly observed. Elderly patients, patients with recurrent gastrointestinal bleeding or ulceration or perforation there will be serious consequences. Serious consequences at any time during treatment, and without warning symptoms before the onset of any symptoms and past medical records. In rare cases, It appears gastrointestinal ulcers or bleeding, then must be immediately suspended. This product with other steroidal anti-inflammatory drugs in combination, one or more liver enzyme values would increase, and resume after the withdrawal, combined, is the first time using this product, allergic reactions, including allergies and or intended to be an allergic reaction. will occur. Long-term using this therapy should have regular monitoring of liver function, kidney function and blood angle. Patients, patients with clinical symptoms of liver disease (eg hepatitis) or other clinical manifestations (such as hypereosinophilic syndrome, rash, etc.), of liver dysfunction should be discontinued. In addition to elevated liver enzyme values, there are few reported cases of serious liver reactions, including jaundice and severe acute hepatitis. Hepatitis can occur in the absence of any prodromal symptoms. Patients with hepatic porphyria should be used with caution, because this product will lead to the onset of hepatic porphyria. Like other non-steroidal anti-inflammatory drugs, this product may mask the clinical symptoms of infection, temporary inhibition of platelet aggregation function. Platelet aggregation dysfunction in patients should be subject to careful monitoring. Special Note: dizziness or other central nervous system disease in patients, including blurred vision in patients. When using this product should not be driving a motor vehicle, should not be to operate the machines. pregnant women and lactating women drug It can be used by animal placenta and a small amount present in the milk of lactating women, pregnant and lactating women disabled. This product is larger dose is not recommended for use by children.drugs in elderly patients elderly medication should be based on the needs and tolerance of dose adjustment, especially for the frail and low-weight patients, must be under the supervision of medication. Like other non-steroidal anti-inflammatory drugs, this product will reduce the effectiveness of diuretics. Will result in hyperkalemia with potassium-sparing diuretics, together with, and therefore should be used to observe the serum potassium concentration. Non-steroidal anti-inflammatory drugs or glucocorticoids associated with the occurrence of adverse reactions will increase. Diabetic drug dosage should be adjusted according to the condition. in the 24 hours before and after the use of methotrexate, the use of non-steroidal anti-inflammatory drugs should be very cautious, because the methotrexate plasma concentration will rise during this period, its toxicity will be increase.  Non-steroidal anti-inflammatory drugs for the role of renal prostaglandins prostate can increase the nephrotoxicity of cyclosporine. There are case reports with non-steroidal anti-inflammatory drugs associated with quinolones may cause convulsions.

Adverse reaction: upper abdominal pain, other gastrointestinal symptoms such as nausea, vomiting, diarrhea, abdominal cramps, indigestion, abdominal distension, anorexia, anorexia,  headache, dizziness, dizziness, skin rash, urticaria, edema, elevated serum transaminases .